Pharmacy to Dose: The Critical Care Podcast
Cerebral Edema Treatment

Cerebral Edema Treatment

April 15, 2020

Cerebral Edema Treatment

Special Guest: Aaron Cook, PharmD, BCCCP, BCPS, FCCP, FKSHP, FNCS 

Show Notes: https://pharmacytodose.files.wordpress.com/2020/04/treatment-of-cerebral-edema-show-notes.pdf

 

Guideline Development

06:18 – How did the content and the chairs for this guideline get chosen?; 08:40 – How long were you working on these guidelines?; 09:40 – How are panel members chosen for the guidelines?; 11:20 – Is the research librarian underrated?; 13:31 – GRADE methodology and PICO formatting; 17:24 – Has this changed your research habits or ideas?; 21:40 – Challenges from meeting virtually when developing the guidelines; 23:53 – How were disagreements settled within the working group?

Management of Cerebral Edema

27:45 – Cerebral edema and elevated ICP; 29:22 – Refractory cerebral edema management; 31:59 – How long was the initial question list?; 35:03 – Quality of evidence; 37:58 – Patient subgroup with the most evidence; 40:10 – Should we be driving up patients’ sodium levels?; 44:56 – Is there a preferred hyperosmolar agent?; 47:45 – Mannitol in acute ischemic stroke; 49:00 – Osmolar therapy and neurologic outcomes; 51:16 – HTS administration; 54:30 – HTS ADE and monitoring; 57:10 – Mannitol osmolality monitoring; 58:20 – Hyperosmolar therapy ADE prevention; 61:00 – Guideline key take-aways; 62:20 – Common research issues

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COVID-19

COVID-19

March 25, 2020

COVID-19

Special Guest: Andrew Barnes, PharmD

Dr. Andrew Barnes joins the podcast to discuss the effects of COVID-19. We talk about what Seattle and the University of Washington are doing to help treat this national pandemic. Plus there are plenty of tips throughout the episode for ways you can adapt to COVID-19 in your hospital or health system.

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Part 3: Critical Care Medication March Madness Bracket

Part 3: Critical Care Medication March Madness Bracket

March 22, 2020

Part 3 Critical Care Medication March Madness Bracket

Downloadable bracket and more available here: https://pharmacytodose.com/2020/03/15/2020-critical-care-medication-march-madness-bracket-and-info/

 

03:01 – Final Four analysis with Matt Rubertus, PharmD, BCCCP

09:11 – Final Four analysis with Josiah Smith, PharmD, BCCCP

17:35 – Final Four analysis with Brian Gilbert, PharmD, BCPS, BCCCP

29:18 – Final Four analysis with Melanie Smith, PharmD, BCPS, BCCCP

 

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Social Media: @PharmacyToDose

Website: PharmacyToDose.Com

Part 2: Critical Care Medication March Madness Bracket

Part 2: Critical Care Medication March Madness Bracket

March 20, 2020

Part 2 Critical Care Medication March Madness Bracket

 Downloadable bracket and more available here: https://pharmacytodose.com/2020/03/15/2020-critical-care-medication-march-madness-bracket-and-info/ 

00:50 – Introduction; 03:23 – Potpourri region analysis with Brian Gilbert, PharmD, BCPS, BCCCP; 43:43 – PAD region analysis with Melanie Smith, PharmD, BCPS, BCCCP 

Email: PharmacyToDose@Gmail.com

Social Media: @PharmacyToDose

Website: PharmacyToDose.Com

Part 1: Critical Care Medication March Madness Bracket

Part 1: Critical Care Medication March Madness Bracket

March 19, 2020

Part 1: Critical Care Medication March Madness Bracket 

Downloadable bracket and more available here: https://pharmacytodose.com/2020/03/15/2020-critical-care-medication-march-madness-bracket-and-info/

00:58 – Bracket announcement, background, rules, and how you can participate!; 10:15 – Cardiac region analysis with Matt Rubertus, PharmD, BCCCP; 40:37 – Infectious Diseases region analysis with Josiah Smith, PharmD, BCCCP

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Immunotherapy Toxicity in the ICU

Immunotherapy Toxicity in the ICU

March 11, 2020

Immunotherapy Toxicity in the ICU
Special Guest: Heather May, PharmD, FCCM, BCPS, BCCCP 

Show Notes: https://pharmacytodose.files.wordpress.com/2020/03/immunotherapy-toxicity-in-the-icu-show-notes.pdf

Show References: https://pharmacytodose.files.wordpress.com/2020/03/immunotherapy-references.pdf

00:52 – Show updates!; 10:50 – Immune system primer; 13:30 – How does CART therapy work?; 16:35 – CART Side effects that lead to the ICU; 17:40 – When does CRS occur and how acute is the presentation?; 20:50 – CRS risk factors; 23:26 – Biomarkers for CRS identification; 25:25 – CRS treatment; 32:30 – CART neurotoxicity; 37:00 – Mechanism of ICANS; 38:00 – ICANS risk factors; 39:30 – ICANS treatment; 42:45 – Where do patients go post-CART?; 47:15 – Examples of immune checkpoint inhibitors; 49:27 – ICI mechanism of action; 51:05 – Immune-related adverse events (irAEs); 55:20 – Which irAEs grades will present to the hospital/ICU?; 57:30 – When do irAEs occur?; 59:28 – irAEs treatment; 64:55 – Downside to treating irAEs?; 68:22 – Do irAEs mean the treatment is working?; 73:12 – Take-home points for immunotherapy toxicity

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2020 SCCM Congress Recap

2020 SCCM Congress Recap

February 19, 2020

2020 SCCM Congress Recap

Special Guest and Official Conference Correspondent: Anthony Hawkins, PharmD, BCCCP

Anthony and I recap the 2020 SCCM Congress discussing everything from the convention center, research presentations, educational sessions, receptions, things we would change, and much more! This episode was recorded live in Orlando, FL.

Show references: https://pharmacytodose.files.wordpress.com/2020/02/2020-sccm-congress-references.pdf

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Acute Kidney Injury

Acute Kidney Injury

February 12, 2020

Acute Kidney Injury (AKI)
Special Guest: Erin Barreto, PharmD, MSc, BCPS, BCCCP, FCCM

Show Notes: https://pharmacytodose.files.wordpress.com/2020/02/aki-show-notes.pdf

Show References: https://pharmacytodose.files.wordpress.com/2020/02/aki-references.pdf

1:10 – Show updates!; 9:15 – Define and classify AKI; 14:45 – Subspecifying the type of AKI; 18:22 – Prevalence of AKI in the ICU; 20:45 – Identification of high-risk patients; 24:43 – Preferred risk prediction tools; 26:12 – Ideal kidney biomarker; 28:28 – Ideal v. current biomarkers; 32:13 – Structural biomarkers; 39:40 – AKI prevention; 44:08 – Kidney/drug dosing equations; 53:49 – Equations in AKI/renal recovery; 56:43 – Cystatin C; 72:19 – What if you don’t use novel biomarkers?; 75:33 – Favorite calculator for AKI clinical risk predictor tool; 77:43 – AKI potpourri; 85:05 – Take-home points

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Life After the ICU: A Personal Experience

Life After the ICU: A Personal Experience

January 29, 2020

Life After the ICU: A Personal Experience
Special Guest: G. Morgan Jones, PharmD, BCCCP, FCCM

Show Notes: https://pharmacytodose.files.wordpress.com/2020/01/life-after-the-icu-show-notes.pdf

Morgan details his incredible journey after a personal experience with PICS and PICS-F.

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PICS

PICS

January 15, 2020

Post-Intensive Care Syndrome (PICS)
Special Guest: Jimmi Hatton Kolpek, PharmD, BSPharm, FCCP, FCCM, FNAP

Show Notes: https://pharmacytodose.files.wordpress.com/2020/01/pics-show-notes.pdf

Show References: https://pharmacytodose.files.wordpress.com/2020/01/pics-references.pdf

00:25 - #PharmacyToRead Update; 10:07 – Why Jimmi is interested in PICS; 12:36 – When did PICS become an ICU focus?; 13:56 – How did PICS get thrust into the spotlight?; 15:40 – Definition of PICS; 16:27 – When does PICS occur?; 19:38 – How common is PICS?; 21:30 – PICS risk factors; 25:35 – How long does PICS last and how does it affect recovery?; 28:55 – Role of peer support; 31:20 – PICS prevention; 38:17 – Medications that can treat/prevent PICS; 41:50 – When to seek help for PICS?; 44:25 – Process for patients being referred to ICU Recovery Clinic; 48:12 – Who makes up the team and what problems are addressed?; 51:18 – What PICS resources are available for patients/families?; 54:35 – Do we prepare patients for what happens after the ICU?; 56:58 – How can we improve?; 59:53 – Take-home points on PICS

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